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iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 278-285 doi: 10.1007/s11684-016-0453-z

Abstract: collected from three pairs of CRC tissue and adjacent normal tissue. iTRAQ-based quantitative proteomic analysisImmunohistochemical analysis also confirmed that TPM2 was barely detected at protein levels in the CRCmolecules for future biomarker applications and provided an efficient approach for the differential analysis

Keywords： iTRAQ     secretome     colorectal cancer     TPM2    

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Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 362-372 doi: 10.15302/J-FASE-2018206

Abstract:

This study compared proteome profiles and morphological changes of rat jejunum in response to differentProteome analysis, histological observation and PEPT1 quantification of the jejunum were performed.

Keywords： Hippo signaling pathway     meat protein     PEPT1     proteome analysis     rat jejunum    

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Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats

LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 39-44 doi: 10.1007/s11684-008-0008-z

Abstract: The aim of this paper is to study the effects of Decoction on the plasma proteome in cirrhotic rats.samples were collected from the inferior vena cava to undergo bi-dimensional electrophoresis (2DE) and analysisThe liver fibrogenesis was assessed using a digital image analysis instrument of Masson’s trichrome stained

Keywords： Decoction intervention     serine/threonine-protein     underwent     Decoction     glutathione peroxidase    

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Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics

Frontiers of Medicine   Pages 993-1005 doi: 10.1007/s11684-023-0989-7

Abstract: Migraine is one of the most prevalent and disabling neurological disease, but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects. Acupuncture is a promising complementary therapy, but further clinical evidence is needed. The influence of acupuncture on migraine is not an immediate effect, and its mechanism remains unclear. This study aims to provide further clinical evidence for the anti-migraine effects of acupuncture and explore the mechanism involved. A randomized controlled trial was performed among 10 normal controls and 38 migraineurs. The migraineurs were divided into blank control, sham acupuncture, and acupuncture groups. Patients were subjected to two courses of treatment, and each treatment lasted for 5 days, with an interval of 1 day between the two courses. The effectiveness of treatment was evaluated using pain questionnaire. The functional magnetic resonance imaging (fMRI) data were analyzed for investigating brain changes induced by treatments. Blood plasma was collected for metabolomics and proteomics studies. Correlation and mediation analyses were performed to investigate the interaction between clinical, fMRI and omics changes. Results showed that acupuncture effectively relieved migraine symptoms in a way different from sham acupuncture in terms of curative effect, affected brain regions, and signaling pathways. The anti-migraine mechanism involves a complex network related to the regulation of the response to hypoxic stress, reversal of brain energy imbalance, and regulation of inflammation. The brain regions of migraineurs affected by acupuncture include the lingual gyrus, default mode network, and cerebellum. The effect of acupuncture on patients’ metabolites/proteins may precede that of the brain.

Keywords： acupuncture     migraine     fMRI     metabolome     proteome    

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15th International Congress for Stereology and Image Analysis 第十五届国际体视学与图像分析学术会议

Conference Date: 27 May 2019

Conference Place: 丹麦/奥胡斯

Administered by: 国际体视学与图像分析学会(ISSIA)

Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation Article

Zhengyi Jiang, Zeyu Sun, Xiaoxi Ouyang, Yalei Zhao, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li

Engineering 2020, Volume 6, Issue 11,   Pages 1302-1314 doi: 10.1016/j.eng.2020.02.011

Abstract: While the transcriptional regulation and whole cell proteome (WCP) of PHCs have been extensively studiedOur data constitute a detailed proteomic analysis of dedifferentiated PHCs including 2196 proteins, 2056A combined analysis of the ubiquitinome with the corresponding WCP indicated that the dedifferentiationFunctional analysis of the altered phosphoproteins suggested a significant enrichment in ferroptosis.Taken together, our data provide new insights into proteome dynamics during PHC dedifferentiation and

Keywords： Ubiquitination     Phosphoproteome     Proteome     Dedifferentiation     Primary hepatocytes    

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Decomposition analysis applied to energy and emissions: A literature review

Frontiers of Engineering Management   Pages 625-639 doi: 10.1007/s42524-023-0270-4

Abstract: Decomposition analysis has been widely used to assess the determinants of energy and CO2 emissionsBoth the methodology and application of decomposition analysis have been largely improved in the pastTo this end, this study presents a literature survey for decomposition analysis applied to energy andtechniques is first conducted, followed by a synthesis of emerging trends and features for the decomposition analysisThe findings are expected to direct future research in decomposition analysis.

Keywords： index decomposition analysis     structural decomposition analysis     production decomposition analysis     energy    

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Flow, thermal, and vibration analysis using three dimensional finite element analysis for a flux reversal

B. VIDHYA,K. N. SRINIVAS

Frontiers in Energy 2016, Volume 10, Issue 4,   Pages 424-440 doi: 10.1007/s11708-016-0423-9

Abstract: A three-dimensional finite element analysis (FEA) based CFD technique for finding the spread of pressureThe results of CFD are mainly obtained to fine tune the thermal analysis.Thus, in this focus, a flow analysis assisted thermal analysis is presented to predict the steady stateThe vibration analysis is illustrated.Harmonic analysis such as sine sweep analysis to identify the range of speeds causing high vibrations

Keywords： flux reversal generator     air velocity     computation fluid dynamics     thermal analysis     vibration analysis     finiteelement analysis    

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Review of sentiment analysis: An emotional product development view

Frontiers of Engineering Management   Pages 592-609 doi: 10.1007/s42524-022-0227-z

Abstract: Given that sentiment analysis (SA) can extract and analyze people’s opinions, sentiments, attitudes,

Keywords： sentiment analysis     emotion     product development     Kansei Engineering    

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Jack up reliability analysis: An overview

Ahmad IDRIS, Indra Sati Hamonangan HARAHAP, Montasir Osman Ahmed ALI

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 4,   Pages 504-514 doi: 10.1007/s11709-017-0443-5

Abstract: Reliability analysis theories are one of the frameworks recommended for the safety assessment of theWith recent developments in uncertainty and reliability analysis of structures subject to stochasticexcitation, this study aims at providing a review on the past developments in jack up reliability analysisThe results from literature reviewed shows that failure probabilities vary significantly with analysisIn addition, from the variants of reliability analysis approach, the method of time dependent reliability

Keywords： jack up     reliability analysis     uncertainty analysis     review of jack up    

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Systems biomedical analysis of Schistosoma japonicum

Ze-Guang HAN MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 157-165 doi: 10.1007/s11684-010-0034-5

Abstract: Human schistosomiasis, caused mainly by three principal species including , , and , remains a major public health concern worldwide. is prevalent in southern China, being a major disease risk for 66 million people. The blood fluke has a complex life cycle for survival: as a free-living form in fresh water and as a parasite in the snail intermediate and vertebrate definitive hosts. Systems-based biomedical analyses, including genomic, transcriptomic, proteomic and metabonomic approaches, have been performed on the schistosome. These comprehensive investigations have not only characterized the genomic features but also chartered gene and protein expression profiles across genders and developmental stages. The integration of the huge information will lay a global and solid foundation for the molecular architecture of the biology, pathogenesis, and host-parasite interactions of the human blood fluke, which will facilitate the development of a new antischistosomal vaccine and drugs as well as diagnostic markers for the treatment and control of schistosomiasis.

Keywords： Schistosoma japonicum     systems biomedical analysis    

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Numerical analysis and experimental investigation of modal properties for the gearbox in wind turbine

Pengxing YI,Peng HUANG,Tielin SHI

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 4,   Pages 388-402 doi: 10.1007/s11465-016-0404-z

Abstract:

Wind turbine gearbox (WTG), which functions as an accelerator, ensures the performance and service life of wind turbine systems. This paper examines the distinctive modal properties of WTGs through finite element (FE) and experimental modal analyses. The study is performed in two parts. First, a whole system model is developed to investigate the first 10 modal frequencies and mode shapes of WTG using flexible multi-body modeling techniques. Given the complex structure and operating conditions of WTG, this study applies spring elements to the model and quantifies how the bearings and gear pair interactions affect the dynamic characteristics of WTGs. Second, the FE modal results are validated through experimental modal analyses of a 1.5 WM WTG using the frequency response function method of single point excitation and multi-point response. The natural frequencies from the FE and experimental modal analyses show favorable agreement and reveal that the characteristic frequency of the studied gearbox avoids its eigen-frequency very well.

Keywords： wind turbine gearbox     modal analysis     finite element analysis     modal frequency     bearing equivalence    

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Isogeometric analysis of coupled thermo-elastodynamic problems under cyclic thermal shock

Asghar AMANI DASHLEJEH

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 2,   Pages 397-405 doi: 10.1007/s11709-018-0473-7

Abstract: The isogeometric analysis (IGA) method was extended for the solution of the coupled thermo-elastodynamicThe results dedicated that IGA can be used as a suitable approach in the analysis of the general thermomechanical

Keywords： isogeometric analysis     coupled thermo-elastodynamic     dynamic analysis     generalized newmark     cyclic thermal    

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Title Author Date Type Operation

iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Journal Article

Proteome comparisons reveal influence of different dietary proteins on the development of rat jejunum

Mengjie LI, Chunbao LI, Shangxin SONG, Xinglian XU, Guanghong ZHOU

Journal Article

Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats

LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong

Journal Article

Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics

Journal Article

15th International Congress for Stereology and Image Analysis 第十五届国际体视学与图像分析学术会议

27 May 2019

Conference Information

黄幼麟: Dynamic Consumer Preferences for Electric Vehicles — A Longitudinal Analysis (2020-7-12)

10 Jun 2022

Conference Videos

Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation

Zhengyi Jiang, Zeyu Sun, Xiaoxi Ouyang, Yalei Zhao, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li

Journal Article

Toshio Fukuda: Bio Cell Analysis and Assembly by Micro and Nano Robotic Technology（2019-8-25）

福田敏男(院士)

20 Jan 2021

Conference Videos

Decomposition analysis applied to energy and emissions: A literature review

Journal Article

Flow, thermal, and vibration analysis using three dimensional finite element analysis for a flux reversal

B. VIDHYA,K. N. SRINIVAS

Journal Article

Review of sentiment analysis: An emotional product development view

Journal Article

Jack up reliability analysis: An overview

Ahmad IDRIS, Indra Sati Hamonangan HARAHAP, Montasir Osman Ahmed ALI

Journal Article

Systems biomedical analysis of Schistosoma japonicum

Ze-Guang HAN MD,

Journal Article

Numerical analysis and experimental investigation of modal properties for the gearbox in wind turbine

Pengxing YI,Peng HUANG,Tielin SHI

Journal Article

Isogeometric analysis of coupled thermo-elastodynamic problems under cyclic thermal shock

Asghar AMANI DASHLEJEH

Journal Article